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CANNABINOID PROFILE – HEXAHYDROCANNABINOL – (HHC)

Hexahydrocannabinol (HHC) is one of the latest novel cannabinoids to come onto the market and its getting a lot of buzz.  Let’s take a look at what is HHC exactly, and what are its potential benefits.

Most bulk wholesale HHC concentrates and high quality HHC products available including HHC distillates, isolates, vapes, edibles, flower, pre-rolls and accessories contain HHC derived from hemp. HHC is usually processed from CBD and converted into HHC through a hydrogenation process. During the process the chemical structure is synthesized into a structure similar to the cannabinoid tetrahydrocannabinol (THC) utilizing a catalyst.  The HHC chemical structure differs from THC only in that it has two additional hydrogen atoms and no double bonds. HHC is found to exist naturally in low amounts in hemp plant seeds and pollen therefore a professional lab setting is used to generate any significant bulk HHC amounts.

Over a dozen different forms of HHC have been discovered so far including some variations that are patented such as 9-HHC and 11 methyl-HHC, and biological versions created in the human gut during the metabolization of THC, including alpha and beta HHC. Discovered in the 1970s by scientists studying the Endocannabinoid system. A further derivative version of HHC was developed in the 1980s by Pfizer.

HHC reported effects are similar to those of Delta 9 THC and include:

Happiness and euphoria

Noticeable body high, physical experience

Strong head buzz, mental experience

Appetite Stimulant, Nausea control

Anxiety relief, Motivational

Sedation, calmness, relaxation,

Pain relief

Anti-Inflammation

Anti- Tumor activity

PROMISING RESEARCH FINDINGS ON HHC

HHC was shown to have a high binding affinity for both CB1 And CB2 cannabinoid receptors in the body.

Anti-tumour activity – https://www.sciencedirect.com/science/article/abs/pii/S0014299910009945 – Novel hexahydrocannabinol analogs as potential anti-cancer agents inhibit cell proliferation and tumor angiogenesis

Hexahydrocannabinolic Acid (HTHCA) and HTCBDA possess significant tumor size reduction properties.

Bloom, A. S., Dewey, W. L., Harris, L. S., & Brosius, K. K. (1977). 9-nor-9beta-hydroxyhexahydrocannabinol, a cannabinoid with potent antinociceptive activity: comparisons with morphine. The Journal of pharmacology and experimental therapeutics, 200(2), 263–270.

Huffman, J. W., Hepburn, S. A., Reggio, P. H., Hurst, D. P., Wiley, J. L., & Martin, B. R. (2010). Synthesis and pharmacology of 1-methoxy analogs of CP-47,497. Bioorganic & medicinal chemistry, 18(15), 5475–5482. https://doi.org/10.1016/j.bmc.2010.06.054