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CANNABINOID PROFILE – TETRAHYDROCANNABINOL (THC)

The most famous cannabinoid Tetrahydrocannabinol (THC) has been studied for its therapeutic potential in neuropathic and chronic pain, migraines, inflammation, appetite stimulation, nausea relief, sleep disorders, and post traumatic stress disorder to name a few. Here are highlights and references to studies demonstrating THC’s potential therapeutic properties.

REFERENCES

Nelson, K., Walsh, D., Deeter, P., & Sheehan, F. (1994). A phase II study of delta-9-tetrahydrocannabinol for appetite stimulation in cancer-associated anorexia. Journal of palliative care.

Jenny, M., Santer, E., Pirich, E., Schennach, H., & Fuchs, D. (2009). Δ9-Tetrahydrocannabinol and cannabidiol modulate mitogen-induced tryptophan degradation and neopterin formation in peripheral blood mononuclear cells in vitro. Journal of neuroimmunology, 207(1-2), 75-82.

Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science https://pubmed.ncbi.nlm.nih.gov/30152161/

The anti-inflammatory and analgesic effects of formulated full-spectrum cannabis extract in the treatment of neuropathic pain associated with multiple sclerosis https://pubmed.ncbi.nlm.nih.gov/32239248/

https://www.uspharmacist.com/article/medical-cannabis-for-chronic-pain

Boehnke KF, Scott JR, Litinas E, et al. Pills to pot: observational analyses of cannabis substitution among medical cannabis users with chronic pain. J Pain. 2019;20(7):830-841

Campbell G, Hall WD, Peacock A, et al. Effect of cannabis use in people with chronic non-cancer pain prescribed opioids: findings from a 4-year prospective cohort study. Lancet Public Health. 2018;3(7):e341-e350

Banerjee S, McCormack S. Medical cannabis for the treatment of chronic pain: a review of clinical effectiveness and guidelines. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health. 2019. www.ncbi.nlm.nih.gov/books/NBK546424.

Hauser W, Finn DP, Kalso E, et al. European Pain Federation (EFIC) position paper on appropriate use of cannabis-based medicines and medical cannabis for chronic pain management. Eur J Pain. 2018;22(9):1547-1564

Vigil JM, Stith SS, Adams IM, Reeve AP. Associations between medical cannabis and prescription opioid use in chronic pain patients: a preliminary cohort study. PLoS One. 2017;12(11):e0187795

Piper BJ, DeKeuster RM, Beals ML, et al. Substitution of medical cannabis for pharmaceutical agents for pain, anxiety, and sleep. J Psychopharmacol. 2017;31(5):569-575

Bettinger JJ, Chu R. The potential of the endocannabinoid system. Practical pain management. www.practicalpainmanagement.com/treatments/pharmacological/analgesics-future-potential-endocannabinoid-system. Updated May 9, 2019. Accessed January 15, 2020

Jensen B, Chen J, Furnish T, Wallace M. Medical marijuana and chronic pain: a review of basic science and clinical evidence. Curr Pain Headache Rep. 2015;19(10):50

Manzanares J, Julian M, Carrascosa A. Role of the cannabinoid system in pain control and therapeutic implications for the management of acute and chronic pain episodes. Curr Neuropharmacol. 2006;4(3):239-257

Oliviera-Fusaro MCG, Zanoni CIS, Dos Santos GG, et al. Antihyperalgesic effect of CB1 receptor activation involves modulation of P2X3 receptor in the primary afferent neuron. Eur J Pharmacol. 2017;798:113-121

Savage SR, Romero-Sandoval A, Schatman M, et al. Cannabis in pain treatment: clinical and research considerations. J Pain. 2016;17:654-668

Boehnke KF, Litinas E, Clauw DJ. Medical cannabis use is associated with decreased opiate medication use in a retrospective cross-sectional survey of patients with chronic pain. J Pain. 2016;17:739-744

Bachhuber M, Arnsten JH, Wurm G. Use of cannabis to relieve pain and promote sleep by customers at an adult use dispensary. J Psychoactive Drugs. 2019;51:400-404

Nielsen S, Sabioni P, Trigo JM, et al. Opioid-sparing effect of cannabinoids: a systematic review and meta-analysis. Neuropsychopharmacology. 2017;42(9):1752-1765

Therapeutic benefits of cannabis: a patient survey – https://pubmed.ncbi.nlm.nih.gov/24765558/