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Cannabidiol (CBD) is a widely researched and studied cannabinoid. Here are some highlights of research findings, studies and antidotal reports of benefits. References are included below.

CBD has an anti-depressant effect by its ability to activate serotonin receptors.

CBD has been shown to help in the mediation of body temperature, inflammation and pain by binding to the TRPV-1 receptor.

CBD helps in the preservation of anandamide, a natural cannabinoid of the human body. It does this by suppressing the enzyme responsible for breaking it down, called fatty acid amide hydroxylase. This results in enhancing the body’s own endocannabinoid system by enabling greater activations of the CB1 receptor by anandamide.

CBD counters the psychoactive effects of THC by opposing the action of THC at the CB1 receptor helping mute the effects.

CBD has been shown to demonstrate anti-tumor activity by down regulating and turning off the over-expression at the mRNA and protein level of the 1D-1 gene, found in some aggressive cancers such as leukemia, pancreatic, ovarian, lung, brain and breast cancer.

CBD in combination with THC and other minor cannabinoids is used in the treatment of spasticity (muscle stiffness/spasm) due to multiple sclerosis (MS) in an approved pharmaceutical medication available in dozens of countries.

The list of conditions with published research, clinical trials underway or completed and antidotal reported benefits derived from CBD is extensive including: Acne, ADD/ADHD, Addiction, AIDS, ALS, Alzheimer’s, Anorexia, Antibiotic Resistance, Anxiety, Atherosclerosis, Arthritis, Asthma, Autism, Bipolar, Cancer, Colitis/ Crohn’s, Depression, Diabetes, Endocrine Disorders, Epilepsy/ Seizure, Fibromyalgia, Glaucoma, Heart Disease, Huntington’s, Inflammation, Irritable Bowel, Kidney Disease, Metabolic Syndrome, Migraine, Mood Disorders, Motion Sickness, Multiple Sclerosis, Nausea, Neurodegeneration, Neuropathic Pain, Obesity, OCD, Osteoporosis, Parkinson’s, Prion/ Mad Cow Disease, PTSD, Rheumatism, Schizophrenia, Sickle Cell Anemia, Skin Conditions, Sleep Disorders, Spinal Cord Injury, Stress, Stroke/ TBI

GNH Benefits of CBD with references and research findings


Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors – PubMed (

Involvement of serotonin-mediated neurotransmission in the dorsal periaqueductal gray matter on cannabidiol chronic effects in panic-like responses in rats – PubMed (

Cannabidiol as a Potential Treatment for Anxiety and Mood Disorders: Molecular Targets and Epigenetic Insights from Preclinical Research – PubMed (

Cannabidiol as a Potential Treatment for Anxiety Disorders (

Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis (

Cannabinoids as novel anti-inflammatory drugs (

A Balanced Approach for Cannabidiol Use in Chronic Pain (

Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors (

Cannabinoids in the management of difficult to treat pain (

Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia – PubMed (

(PDF) Cannabinoids, Blood–Brain Barrier, and Brain Disposition (

US Govt. Patent #6,630,507 Cannabinoids as Antioxidants and Neuroprotectants

Cannabidiol Counteracts the Psychotropic Side-Effects of Δ-9-Tetrahydrocannabinol in the Ventral Hippocampus through Bidirectional Control of ERK1–2 Phosphorylation | Journal of Neuroscience (

Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects – PubMed (

A Review on Studies of Marijuana for Alzheimer’s Disease – Focusing on CBD, THC (

Cannabidiol as a potential treatment for psychosis (

Cannabinoids and omega-3/6 endocannabinoids as cell death and anticancer modulators – ScienceDirect

Appraising the “entourage effect”: Antitumor action of a pure cannabinoid versus a botanical drug preparation in preclinical models of breast cancer – PubMed (

Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway: novel anti-tumor mechanisms of Cannabidiol in breast cancer – PubMed (